Synthesis and Biological Evaluation of Some New 1-Pheyl, 3-Ethoxycarbonyl, 5-Hydroxy Indole Derivatives as a Potential Antimicrobial Agents
Keywords:
biological evaluation, Indole derivatives potential and microbial agents
Abstract
The derivatives of Indole show biological activities including herbicidal The newly synthesized compounds 1- phenylethyl 2-methyl 3-ethoxy carbonyl 5-methoxycarbonyl 2- methoxy Indole Compound 2 were prepared by treating 1- phenyl 3-ethoxycarbonyl 5-hydroxy 2-methyl Indole Com-pound 1 successively with methyl bromo- acetate and refluxing with K2CO3 KI in the presence of dry acetone Newly synthesized compound 2 refluxed with hydrazine hydrate in alcoholic media forming 1-Phenylethyl 3-ethoxy carbonyl 2-methyl Indole 5-yl oxy acetic acid hydrizide Compound 3 This drug which on separately reacting with carbon disulphide phenyl iso-thiocynide acetylacetone triethylorthoformate gave condensed bridge head heterocyclic s such as 1-Phenyl ethyl 2-methyl 3-ethoxy cabonyl 5 5 -mercapto 1 -3 -4 -oxadiazol 2 -yl -methoxy Indole Compound 4
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Published
2012-05-15
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