Evaluation of 6, 8-Dichloro-2-Methyl-4H-Chromen-4-One Derivatives as Antileishmanial Agents

Authors

  • Hassan M.F.Madkour

  • Dr. Nizam Baloch

Keywords:

2-methyl-4h-chromen-4-one, carbon electrophiles and nucleophiles, leishmaniasis

Abstract

The present work aims at study of antileishmanial activity of some 6, 8-dichloro-2-methyl-4H-chromen-4-one derivatives. The synthesized chromenes have been screened for antileishmanial activity on L. major parasite. The results were promising and showed that all compounds under investigation have some degree of activity against leishmania L. major parasite and compound 5 showed potential activity with IC50 value 0.58± 0.09 μg/ml, comparatively with the standard drug Amphotericin B.

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How to Cite

Hassan M.F.Madkour, & Dr. Nizam Baloch. (2012). Evaluation of 6, 8-Dichloro-2-Methyl-4H-Chromen-4-One Derivatives as Antileishmanial Agents. Global Journal of Science Frontier Research, 12(B7), 27–32. Retrieved from https://journalofscience.org/index.php/GJSFR/article/view/446

 
Evaluation of 6, 8-Dichloro-2-Methyl-4H-Chromen-4-One Derivatives as Antileishmanial Agents

Published

2012-05-15

Issue

Vol. 12 No. B7 (2012): GJSFR-B Interdisciplinary: Volume 12 Issue B7

Section

Articles

License

Copyright (c) 2012 Authors and Global Journals Private Limited

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.