Chiral Inversion of Ibuprofen after an Oral Administration under Complete Fasting and Fed Conditions in Caucasian Healthy Subjects
DOI:
https://doi.org/10.34257/GJSFRBVOL21IS2PG1Keywords:
ibuprofen chiral inversion, stereos elective pharmacokinetics
Abstract
Background: The aim was to determine the effect of feeding on chiral inversion of Ibuprofen isomers.Method: Six healthy volunteers participated in a two-treatment crossover study where a single dose of Ibuprofen racemate was given. One stage consisted in an 8-hour interval of fasting, while in the other, the drug was administered with a solution of saccharose and a standard food intake regimen was implemented. Results: Higher (p<0.01) S/R area under concentration-time curve ratios were achieved in the Fed stage (1.44) compared to the Fasting stage (0.976). Half-life of R-ibuprofen was significantly diminished (p<0.001) under fed conditions. Conclusions: Clearance of R-ibuprofen increased following the ingestion of saccharose and food, however, the increased bioavailability of S-ibuprofen due to R-to-S chiral inversion overrode its increased clearance. This increased inversion might be explained by the supplementary amount of drug molecules that reaches the enter ocytes through pancreatic/intestinal juice secretion following the ingestion of food.
Downloads
- Article PDF
- TEI XML Kaleidoscope (download in zip)* (Beta by AI)
- Lens* NISO JATS XML (Beta by AI)
- HTML Kaleidoscope* (Beta by AI)
- DBK XML Kaleidoscope (download in zip)* (Beta by AI)
- LaTeX pdf Kaleidoscope* (Beta by AI)
- EPUB Kaleidoscope* (Beta by AI)
- MD Kaleidoscope* (Beta by AI)
- FO Kaleidoscope* (Beta by AI)
- BIB Kaleidoscope* (Beta by AI)
- LaTeX Kaleidoscope* (Beta by AI)
How to Cite
Published
2021-05-15
Issue
Section
License
Copyright (c) 2021 Authors and Global Journals Private Limited
This work is licensed under a Creative Commons Attribution 4.0 International License.