The synthesis of novel non-linear polycyclic diazaphenothiazine and its amido derivatives via Buchwald – Hartwig reaction protocol is reported. By reacting 2-amino-5- bromopyrazine-3[4H ]-thione and 2, 3-dichloro-1, 4- naphthoquinone in the presence of anhydrous sodium carbonate, 9-bromo-6-chloro-8, 11-daiza-5H-benzo[a] phenothiazin-5-one was obtained. The arylation of 9-bromo- 6-chloro-8, 11-daiza-5H-benzo[a]pheno-thiazin-5-one with some amides under palladium catalysis gave the amido derivatives in good yield. The stability of these cyclic quinoneimine systems, which has been attributed to ionic resonance effect, is noted. Structural assignments were based on UV, IR and NMR spectra as well as elemental analysis. These compounds showed significant antimicrobial activity against E. coli, Staphylococcus spp, Bacillus spp. and Pseudomonas aeruginosa at varying concentrations.

How to Cite
ULOMA GODWIN–NWAKWASI, UCHECHUKWU CHRIS. OKORO, MERCY AMARACHUKWU EZEOKONKWO, IFEOMA CHINYERE UGWU, FIDELIA NGOZI IBEANU, Evelyn. Metal Catalyzed Synthesis and Antimicrobial Studies of some New Amido Derivatives of Non-Linear Polycyclic Diazaphenothiazinone. Global Journal of Science Frontier Research, [S.l.], june 2019. ISSN 2249-4626. Available at: <https://journalofscience.org/index.php/GJSFR/article/view/2483>. Date accessed: 24 july 2019.