Abstract

A differential pulse voltammetric method has been developed and certify for the cefdinir expected in special pharmaceuticals The polarographic behavior of cefdinir was studied at dropping mercury electrode versus Ag AgCl Cefdinir show clear reversible catholic reduction peak at approximately - 0 518 V in Britton Robinson buffer at pH 4 and 7 in 0 06M KNO3 or 0 01M LiCl whereas the calculated value of the peak potential Ep using Ilkovic - Heyrovsky equation was -0 504V The choicest planned reduction mechanism recommended that the azomethine group get reduce via a four electrons process closely required for the reduction The linear range was recognized between 0 875- 7 000 g ml-1 The calculated results show that LOD and LOQ were equals to 0 3271and 1 0904 g ml-1 respectively This method was successfully applied to assay cefdinir in commercial capsules with 0 089 standard deviation and relative standard deviation less than 2 97 The proposed method is simple accurate fewer time consuming and even applied without prior separation for the color and excipient solution