Abstract

Background: Allergi rhinitis(AR) is a significant cause of widespread morbidity, high medical treatment costs,reduced work productivity,lowquality of life and can be associated with conditions such as fatigue, headache, cognitive impairment, and sleep disturbance. Aim of the study: To find out the relation between tumour necrosis factor alpha (TNF) and Zn/Cu ratioin the patients with mild or moderate/severe cases. Patients and Methods: Ninety subject were enrolled in this study .Fifty patients with AR were subdivided into two groups i.e. mild (comprising 20 patients) with AR , moderate/ severe (comprising 30 patients) with AR . Forty subjects who are apparently healthy were taken as a control group. Serum TNF- was determind by using enzyme- linked immunosorbent assay (ELISA). Zn and Cu were determined by using colorimetric method. Results: Serum levels of TNF- was significantly higher in mild and moderate/severe groups compared with control group (p<0.01).A significant positive correlation between TNF- and copper. A significant negative correlation between TNF- and zinc in AR patients in mild and moderate/severe cases. Conclusion: Zn/Cu ratio affect TNF- level in patients with AR.