Possible Protective Role of Ginger Extract on Methomyl Induced Hepatotoxicity in Adult Male Albino Rats
methomyl, hepatotoxicity and ginger extract
Abstract
This study aimed to evaluate the possible histological and ultrastructural changes of liver induced by methomyl pesticide exposure and estimation the possible protective effect of ginger extract for hepatic damage in rats. Ginger is used worldwide primarily as a spicy condiment and of the herbal sources of natural protection from contamination and oxidative stress thus play an important role in chemoprevention of liver diseases. Methomyl is one of the most frequently prescribed pesticides, that are used as a pesticide. It is characterized as a highly toxic compound and has been reported to cause multiple organs damage. Fifteen male albino rats were allocated into 5 main groups. (3 rats in each); one served as control and the four remained groups were for different treatments. GC-MS analysis of ginger extract revealed the content of gingerol, quercetin (3.20%), limonene and zingiberene. Treatment of methomyl treated rats with ginger extract maintained serum ALP, AST& ALT levels and reduced the damage effect with protective efficacy against pesticide induced hepatotoxicity, which appears also more effective than its therapeutic application.
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Suvarna Kim, S, Christopher Layton, Bancroft John, D (2012) Bancroft's Theory and Practice of Histological Techniques.
(2022) Unknown Title. 65(8), 520-556.
T Ajith, V Nivitha, S Usha (2007) Zingiber officinale Roscoe alone and in combination with α-tocopherol protect the kidney against cisplatin-induced acute renal failure. 45(6), 921-927.
W Li, X Zhang, Y Wu (2001) Antiinflammatory effect and mechanism of proanthocyanidine from grape seeds. 22, 1117-1120.
K Mallikarjuna, P Sahitya Chetan, K Sathyavelu Reddy, W Rajendra (2008) Ethanol toxicity: Rehabilitation of hepatic antioxidant defense system with dietary ginger. 79(3), 174-178.
Stanley Reitman, Sam Frankel (1957) A Colorimetric Method for the Determination of Serum Glutamic Oxalacetic and Glutamic Pyruvic Transaminases. 28(1), 56-63.
C Huang, J Horng, Yin Mc (2004) Antioxidative and antiglycative effects of six organosulfur compounds in low density lipoprotein and plasma. 52(11), 3674-3678.
Temidayo Omobowale, Ademola Oyagbemi, Akinleye Akinrinde, Adebowale Saba, Oluwabusola Daramola, Blessing Ogunpolu, James Olopade (2014) Failure of recovery from lead induced hepatoxicity and disruption of erythrocyte antioxidant defence system in Wistar rats. 37(3), 1202-1211.
R Kondeti, M Korivi, N Kesireddy, C Kuo, S Kiesireddy (2011) Protective effect of dietary ginger on antioxidant enzymes and oxidative damage in experimental diabetic rat tissues. 124(4), 1436-1442.
Oecd Guideline For Testing Of Chemicals (2001) Test No. 425: Acute Oral Toxicity: Up-and-Down Procedure. 324.
A Farag (2005) Deterimenral effects of certain pesticides on white albino rat (Rattus norvrgicus Boric).
(2005) Microcomputer Program Analysis Version. 6, 311.
A El-Sharaky, A Newairy, M Kamel, S Eweda (2009) Protective effect of ginger extract against bromobenzene-induced hepatotoxicity in male rats. 47(7), 1584-1590.
M Powell, M Smith (1954) The Determination of Serum Acid and Alkaline Phosphatase Activity with 4-Aminoantipyrine (A.A.P.). 7(3), 245-248.
Giacomo Certini (2005) Effects of fire on properties of forest soils: a review. 143(1), 1-10.
Yun-An Chen, Pao-Wen Grace Liu, Liang-Ming Whang, Yi-Ju Wu, Sheng-Shung Cheng (2020) Effect of soil organic matter on petroleum hydrocarbon degradation in diesel/fuel oil-contaminated soil. 129(5), 603-612.
Dilfuza Egamberdieva, Stephan Wirth, Undine Behrendt, Elsayed Abd_Allah, Gabriele Berg (2016) Biochar Treatment Resulted in a Combined Effect on Soybean Growth Promotion and a Shift in Plant Growth Promoting Rhizobacteria. 7, 209.
Dagmar Etkin (2001) ANALYSIS OF OIL SPILL TRENDS IN THE UNITED STATES AND WORLDWIDE. 2001(2), 1291-1300.
S Gan, E Lau, H Ng (2009) Remediation of soils contaminated with polycyclic aromatic hydrocarbons (PAHs). 172(2-3), 532-549.
G Giovannini, S Lucchesi, M Giachetti (1988) EFFECT OF HEATING ON SOME PHYSICAL AND CHEMICAL PARAMETERS RELATED TO SOIL AGGREGATION AND ERODIBILITY. 146(4), 255-261.
R Haynes, R Swift (1989) Effect of rewetting air-dried soils on pH and accumulation of mineral nitrogen. 40(2), 341-347.
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2023-02-21
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