Abstract

This study aimed to evaluate the possible histological and ultrastructural changes of liver induced by methomyl pesticide exposure and estimation the possible protective effect of ginger extract for hepatic damage in rats Ginger is used worldwide primarily as a spicy condiment and of the herbal sources of natural protection from contamination and oxidative stress thus play an important role in chemoprevention of liver diseases Methomyl is one of the most frequently prescribed pesticides that are used as a pesticide It is characterized as a highly toxic compound and has been reported to cause multiple organs damage Fifteen male albino rats were allocated into 5 main groups 3 rats in each one served as control and the four remained groups were for different treatments GC-MS analysis of ginger extract revealed the content of gingerol quercetin 3 20 limonene and zingiberene Treatment of methomyl treated rats with ginger extract maintained serum ALP AST ALT levels and reduced the damage effect with protective efficacy against pesticide induced hepatotoxicity which appears also more effective than its therapeutic application Coadministration of methomyl with ginger extract showed a slight improvement in some hepatocytes that looked normal in the examination but still markedly affected and showing signs of degeneration Results obtained in this study demonstrated that high doses of methomyl induced histological and ultrastructural changes in the liver and the levels of enzymes were raised due to oxidative stress and the use of ginger extract had partially improved the toxic effect of methomyl