Abstract

This review discusses how we use the most common and novel synthesized active methylene compounds as well as heterocycles having active methyl or methine in the syntheses of a wide variety of substituted and fused pyridines interesting medical and pharmaceutical importance Many synthetic approaches were used for the preparation of target heterocyclic systems such as cyclocondensation reactions ring opening-ring closure cycloaddition acid- or base-catalyzed reaction intermolecular cyclization and self-condensation have been reviewed in this paper Also the antimicrobial activity carried out on some newly selected synthesized pyridines and their fused derivatives were reported