Serum Homocysteine and Paraoxonase 1 Levels in Women with Polycystic Ovary Syndrome Treated with Metformin Versus Metformin and Folic Acid

Dr. Tarek H. Abed Tawfik Al-Khyat; qusaym64

Authors

Dr. Tarek H. Abed Tawfik Al-Khyat
qusaym64

patients Besides, increase homocysteine levels significantdecreasein thelevels

Abstract

Background: Polycystic ovary syndrome (PCOS) is the most common reproductive endocrinopathy and currently considered to be a part of the metabolic syndrome. Women with PCOS cluster risk factors associated with risk of atherosclerosis. These risk factors include insulin resistance, dyslipidemia, hyperandrogenemia, obesity, endothelial dysfunction and oxidative stress. Aim of the study: Study of the relationship between homocysteine and paraoxonase 1 in PCOS in two different regimes of treatment with Metformin and Folic acid in order to elucidate some risk factors that may lead to atherosclerosis and vascular diseases in the corresponding patients. Patients and Methods: Fifty patients with PCOS were enrolled in this study that subdivided into two groups according to type of treatment received i.e. G1 (comprising 25 patients) treated with Metformin only, G2 (comprisin25 patients) with Metformin and Folic acid. Serum Homocysteine (Hcy), Paraoxonase 1(PON1) Apolipoprptein A-1(Apo A-1) and Apolipoprotein B(Apo B) were determind by using enzyme- linked immunosorbent assay (ELISA). Reduced Glutathion (GSH) and Malondialdehyde (MDA) were determined by using colorimetric method. Results: The results indicated a significant increase in the serum levels of Hcy(p

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Serum Homocysteine and Paraoxonase 1 Levels in Women with Polycystic Ovary Syndrome Treated with Metformin Versus Metformin and Folic Acid. (2013). Global Journal of Science Frontier Research, 13(43), 35-40. https://journalofscience.org/index.php/GJSFR/article/view/

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