Ultravist Studies on the Histology Patterns of the Kidney of Adult Wistar Rats

Abstract

The aim of this study was to assess the effects of ultravist on the histological patterns of the kidney of the Wistar rat. Thirty (30) Wister rats weighing between 182-212kg/BW were divided into three groups of ten (10) animals each. Group A served as the control group, while group B and C served as experimental groups receiving low and high dosage of ultravist (iopromide) which is the Radiographic Contrast Medium (RCM) used for the experiment respectively. Collection of tissues was carried out on rats at intervals of 30 minutes, 60 minutes, 2 hours, 12 hours and 24 hours following administration of RCM on the experimental groups. The sampling from experimental and control groups were carried out simultaneously following administration of low and high dose of RCM to rats from experimental groups. The result obtained for ultravist after one hour administration presented in plates 2 and 4 showed alteration in the high dose animals while plates 3 and 5 showed marked alterations in the cellular morphology of the kidney of the low dose animals. The alterations included swollen or oedematous glomeruli, swollen epithelial cells, loss of Bowman's space and hyper cellular mesangium (proliferation of cells in the mesangium). The implication is that cells in this condition cannot perform the primary functions of secretion and excretion or maintaining the glomerular filtration rate within the normal range of arterial pressure of approximately 80 to 180 mmHg. The consequence of these changes in the cells may lead to a number of physiological manifestations such as acute renal failure.