Genomic Diversity and Affinities among Four Dravidian Tribal Populations of South India: A Study on Eighteen Autosomal DNA Markers

A. Krishnaveni; K. Prabhakaran

Authors

A. Krishnaveni
K. Prabhakaran

genomic diversity, dravidian tribes, heterozygosity, genetic distance, alu indels, RSPs

Abstract

Polymorphic DNA markers are widely used to study genomic diversity, as most of them are selectively neutral, more ubiquitous than polymorphic protein and enzyme markers. Therefore, it is of great interest to study the genomic diversity and their relationships among the four south Indian tribal populations DNA samples from 190 unrelated individuals belonging to four Dravidian tribal populations viz. Malaikuravan, Malasar, Palliyan and Kattunaikkan were analysed by nine human specific insertion / deletion polymorphic loci and nine restriction site polymorphic loci to ascertain their genomic diversity and affinities with other Indian tribal populations. The results indicate that most of the studied loci are highly polymorphic in terms of allele frequencies (average allele frequency=0.51) and average heterozygosity (H T = 0.49) in all the study populations. The genomic diversity (G ST ) of the four tribal populations was comparatively low (0.032).

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Genomic Diversity and Affinities among Four Dravidian Tribal Populations of South India: A Study on Eighteen Autosomal DNA Markers. (2015). Global Journal of Science Frontier Research, 15(36), 13-21. https://journalofscience.org/index.php/GJSFR/article/view/

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References

(2001) Registrar General and Census commissioner, Government of India. http://www.censusindia.net/

S. Fuchs (1964) Anthropometry of the Gujarat tribes. 263-275.

N. Ray (1973) Nationalism in India: Aligarh Muslim University, Aligarh, India.

K. Singh (1992) People of India: An Introduction Anthropological Survey of India.

S. Fuchs (1973) Aboriginal Tribes of Eastern India. New Delhi. 14(2), 101-105.

Deininger PL, Sherry ST, Rish G (1999) Interspersed Repeat Insertion Polymorphisms for Studies of Human Molecular Anthropology. 201-212. https://doi.org/10.1007/978-1-4615-4263-6_14

Batzer MA, Stoneking M, Alegria-Hartman M (1994) African origin of human-specific polymorphic Alu insertions. 91(25), 2288-1229. https://doi.org/10.1073/pnas.91.25.12288

Stoneking M, Fontius JJ, Clifford SL (1997) AluInsertion Polymorphisms and Human Evolution: Evidence for a Larger Population Size in Africa. 7(11), 1061-1071. https://doi.org/10.1101/gr.7.11.1061

Malhotra KC, Vasulu TS (1993) Structure of human populations of India. In: Majumder PP, editor. Human population genetics. 207-275.

Novick GE, Batzer MA, Deininger PL, Herrera RJ (1996) The mobile genetic element Alu in alcoholism and haplotypes. 16, 33-45.

Novick GK, Novick CC, Yunis J (1998) Polymorphic Alu insertions and the Asian origin of Native American populations. 70(1), 23-39.

Prescott Deininger, Mark Batzer (1999) Alu Repeats and Human Disease. 67(3), 183-193. https://doi.org/10.1006/mgme.1999.2864

Victoria Belancio, Dale Hedges, Prescott Deininger (2008) Mammalian non-LTR retrotransposons: For better or worse, in sickness and in health. 18(3), 343-358. https://doi.org/10.1101/gr.5558208

Mark Batzer, Prescott Deininger (2002) Alu repeats and human genomic diversity. 3(5), 370-379. https://doi.org/10.1038/nrg798

Vasudeva Murthy, Lim Jia, Vijaya Samuel, Kumaraswamy Kademane (2015) Forensic identification by using insertion deletion Polymorphisms. 15(2), 55-59. https://doi.org/10.1080/09723757.2015.11886253

Singh K, Bourque G, Craig L, Duvnau JT, Feschoitte C, Flasch DA, Gunderson KL, Malik HS, Moran JV, Peters JE, Slotkin RK (2014) Mobile genetic elements and genome evolution 2014. 5(1), 26. https://doi.org/10.1186/1759-8753-5-26

(1996) Global Patterns of Linkage Disequilibrium at the CD4 Locus and Modern Human Origins. 271(5254), 1380-1387. https://doi.org/10.1126/science.271.5254.1380

Ahmet Inanir, Abdullah Cenikli, Ercan Tural, Akin Tekcan, Sengul Tural, Duygu Cakil, Serbulent Yigit (2014) Molecular Analysis of Genetic Variation in Angiotensin I-Converting Enzyme Gene in Turkish Athletes. 14(2), 101-105. https://doi.org/10.1080/09723757.2014.11886232

Majumder PP, Roy B, Banerjee S, Chaktraborty M, Dey B, Mukherjee N, Roy M, Thakura PG, Sil SK (1999) Human-specific insertion/deletion polymorphisms in Indian populations and their possible evolutionary implications. 7(4), 435-446. https://doi.org/10.1038/sj.ejhg.5200317

Jorde LB, Watkins Bamshad M.J, Fraley Zenger R, Carpenter Krakowiak PA, Jenkins Soodyall H, Rogers AR (1995) Origins and affinities of modern humans: A comparison of mitochondrial and nuclear genetic data. American. 57, 523-538.

KK Kidd, B. Morar, C. Castiglione (1998) A global survey of haplotype frequencies and linkage disequilibrium at the DRD2 locus. 103(2), 211-227. https://doi.org/10.1007/s004390050809

W. Watkins, C. Ricker, M. Bamshad, M. Carroll, S. Nguyen, M. Batzer, H. Harpending, A. Rogers, L. Jorde (2001) Patterns of Ancestral Human Diversity: An Analysis of Alu-Insertion and Restriction-Site Polymorphisms. 68(3), 738-752. https://doi.org/10.1086/318793

Vishwanathan H, Deepa E, Usha MV, Majumder PP (2003) Insertion/Deletion Polymorphisms in Tribal Populations of Southern India and Their Possible Evolutionary Implications. 75(6), 873-887.

Nei M (1973) Analysis of Gene Diversity in Subdivided Populations. 70, 3321-3323.

T. Ota (1993) DISPAN: Genetic Distances and Phylogenetic Analysis.

Harpending HC, Ward (1982) Chemical systematic and human evolution. 213-256.

Veerraju P, Demarche DA, Lakshmi N, Rao VT (2008) Insertion/Deletion Polymorphisms in Indian Tribal Populations. 8(1-2), 75-83. https://doi.org/10.1080/09723757.2008.11886021

K. Saraswathi, M. Sachdeva, R. Mokhopadhyay, D. Shukla, Kiranmala Devi, N. Rawat, S. Rao, A. Kalla, A. (2008) Diversified genomic contribution among south Indian populations- A study on four endogamous groups of Andhra Pradesh. 35(5), 499-508.

S. Kanthimathi, M. Vijaya, A. Ramesh (2008) Genetic study of Dravidian castes of Tamil Nadu. 87(2), 175-179. https://doi.org/10.1007/s12041-008-0027-1

Abhay Yadav, Preeti Arora (2011) Genomic diversities and affinities among eight endogamous groups of Haryana (India): A study on insertion/deletion polymorphisms. 38(1), 114-118. https://doi.org/10.3109/03014460.2010.492949

Dada R, Saraswathy KN, Mettei KS, Mondal PR, Kaur H, Kucheria K, Bhardwaj S, Idris G (2011) Genetic sketch of the six population groups of Rajasthan: a study based on 12 autosomal loci. 119(3), 259-264. https://doi.org/10.1537/ase.100826

Gautam Kshatriya, Aastha Aggarwal, Priyanka Khurana, Yazdi Italia (2011) Genomic congruence of Indo-European speaking tribes of western India with Dravidian-speaking populations of southern India: A study of 20 autosomal DNA markers. 38(5), 583-591. https://doi.org/10.3109/03014460.2011.577455

Rakesh Panjaliya, Vikas Dogra, Parvinder Kumar, Subash Gupta (2012) Human-specificAluInsertion/Deletion Polymorphisms in Various Population Groups of Jammu Region. 12(4), 311-317. https://doi.org/10.1080/09723757.2012.11886185

Namita Mukherjee, Mitashree Mitra, Madan Chakraborty, Partha Majumder (2000) Congruence of genomic and ethnolinguistic affinities among five tribal populations of Madhya Pradesh (India). 79(2), 41-46. https://doi.org/10.1007/bf02728944

H. Vishwanathan, E. Deepa, R. Cordaux, M. Stoneking, M. Usha Rani, P. Majumder (2004) Genetic structure and affinities among tribal populations of southern India: a study of 24 autosomal DNA markers. 68(2), 128-138. https://doi.org/10.1046/j.1529-8817.2003.00083.x

Revathi Rajkumar, V. Kashyap (2004) Genetic structure of four socio-culturally diversified caste populations of southwest India and their affinity with related Indian and global groups. 5(1), 23. https://doi.org/10.1186/1471-2156-5-23

R. Thapar (1966) A history of India. 1.

F. Yeh, R. Yang (1999) A joint project development: POPGENE 1. 32.