Is it Possible Artificial Sex Regulation in Mammals?
sex differentiation; sex regulation; cell thermoregulation; constitutive heterochromatin; Y chro-mosome; genital ridges; non coding DNAs
Abstract
In spite of, impressive breakthrough in modern genetics and molecular biology the problem of artificial sex regulation of mammals still remains unsolved. Moreover, the very problem of sex origin of eukaryotes in the process of evolution still has not settled. Existing theories and hypothesizes mainly concern the maintenance and biological reasonability of sexual mode of replication. Their theoretic foundation is based on Darwin's and Mendel's ideas that sex was originated due to natural selection and genes. On the basis of other model of genesis and sex evolution of eukaryote, it was suggested the idea of artificial sex regulation of mammals. Seemingly, the sex differentiation (SD) in animals and human is determined by the amount of constitutive heterochromatin region (cHR) in the Y chromosomes of the undifferentiated embryonic gonads (UEG) via cell thermoregulation. It is assumed the medulla and cortex tissue cells in the UEG differ in vulnerability to the increase of the intracellular temperature because of their anatomical position in genital ridges. If the amount of the cHR on Y chromosome is enough for efficient elimination of redundant metabolic heat from rapidly growing UEG cells the medulla tissue survives. Otherwise it doomed to degeneration and a cortex tissue will remain in the UEG. For artificial regulation of the SD it is proposed to remove a layer of cortex in the UEG.
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References
Calvin Bridges (1925) Sex in Relation to Chromosomes and Genes. 59(661), 127-137. https://doi.org/10.1086/280023
Burgoyne PS, Thornhill AR, Kalmus S, Darling SM, Bishop CE, Evans EP (1995) The genetic basis of XX-XY differences present before gonadal sex differentiation in the mouse. 350(1333), 253-261. https://doi.org/10.1098/rstb.1995.0159
R. Goldschmidt (1955) Theoretical Genetics.
Vincent Harley, David Jackson, Patrick Hextall, J. Hawkins, Gary Berkovitz, Shanthini Sockanathan, Robin Lovell-Badge, Peter Goodfellow (1992) DNA Binding Activity of Recombinant SRY from Normal Males and XY Females. 255(5043), 453-456. https://doi.org/10.1126/science.1734522
A. Ibraimov (2003) Condensed Chromatin and Cell Thermoregulation. 1(4), 164-170. https://doi.org/10.1159/000081065
A. Ibraimov (2004) The Origin of Condensed Chromatin, Cell Thermoregulation and Multicellularity. 2(1), 23-34. https://doi.org/10.1159/000087851
A. Ibraimov, S. Tabaldiev (2007) Condensed Chromatin, Cell Thermoregulation and Human Body Heat Conductivity. 21(1), 1-22. https://doi.org/10.1080/09709274.2007.11905944
A. Ibraimov (2008) Possible mechanism of the sex differentiation and its artificial regulation. 8(3), 283-290. https://doi.org/10.1080/09723757.2008.11886041
A. Ibraimov (2009) Noncoding DNAs and origin of sex. 9(1), 39-47. https://doi.org/10.1080/09723757.2009.11886059
A. Ibraimov (2010) Noncoding DNAs in Development and Evolution. In: Bhasin MK, Susanne C (Eds.): Anthropology Today: Trends and Scope of Human Biology. 199-224.
A. Ibraimov, A. Kazakova, I. Moldotashev, M. Sultanmuratov, K. Abdyev (2010) Variability of Human Body Heat Conductivity in Population I. Methodological and Theoretical Approaches. 32(1), 1-22. https://doi.org/10.1080/09709274.2010.11906316
A. Ibraimov, A. Kazakova, I. Moldotashev, M. Sultanmuratov, K. Abdyev (2010) Variability of Human Body Heat Conductivity in Population II. Diseases of Civilization. 32(2), 69-78. https://doi.org/10.1080/09709274.2010.11906323
A. Ibraimov (2011) Origin of modern humans: а cytogenetic model. 26(1-2), 33-47.
Ibraimov AI (2012) on the origin of sex. (8), 1-6.
Jost A (1972) A new look at the mechanisms controlling sex differentiation in mammals. 130, 38-53.
Peter Koopman, John Gubbay, Nigel Vivian, Peter Goodfellow, Robin Lovell-Badge (1991) Male development of chromosomally female mice transgenic for Sry. 351(6322), 117-121. https://doi.org/10.1038/351117a0
Lyon MF (1992) SOME MILESTONES IN THE HISTORY OF X-CHROMOSOME INACTIVATION. 26, 17-28.
Ohno S, Tettenbroun U, Dofuku R (1971) Molecular biology of sex differentiation1. 69(1), 107-124. https://doi.org/10.1111/j.1601-5223.1971.tb02423.x
A. Pontiggia, R. Rimini, V. Harley, P. Goodfellow, R. Lovell‐badge, M. Bianchi (1994) Sex‐reversing mutations affect the architecture of SRY‐DNA complexes. 13(24), 6115-6124. https://doi.org/10.1002/j.1460-2075.1994.tb06958.x
Prokofyeva-Belgovskaya AA (1986) Heterochromatic Regions of Chromosomes (in Russian).
M. Ridley (2001) the Cooperative Gene. The Free Press. 108-111.
Dagmar Wilhelm, Stephen Palmer, Peter Koopman (2007) Sex Determination and Gonadal Development in Mammals. 87(1), 1-28. https://doi.org/10.1152/physrev.00009.2006
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2013-09-09
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