Abstract

Inflammation is a part of the complex biological response of vascular tissues to harmful stimuli such as pathogens damaged cells or irritants This study is aimed at evaluating the invitro anti-inflammatory potential of aqueous leaves extract of Solanum aethiopicum Family Solanaceae In vitro anti-inflammatory potentials were evaluated using standard experimental protocols such as Inhibition of albumin denaturation Anti-lipoxygenase activity Membrane stabilization and Proteinase inhibitory action at different concentrations with aspirin and diclofenac used as the standard drug Aqueous extract of S aethiopicum leaves were tested for the presence of alkaloid flavonoid tannin glycoside steroids phenol and terpenoids The total phenol and flavonoid content were evaluated as well The total phenol and flavonoid content were found to be 132 0 13 mg of Gallic acid g of equivalent and 146 1 12mg of Quercetin g of equivalent The IC50 values of the extract diclofenac and aspirin standard drug in inhibition of albumin denaturation were 50 20 g ml and 31 54 g ml in Anti-lipoxygenase activity were 199 g ml and 28 2 g ml in Membrane stabilization were 9 36 g ml and 19 85 g ml and Protein Denaturation 714 g ml and 23 5 g ml The Inhibition of membrane stabilization might be the possible mechanism by which the extract elicits its antiinflammatory effect The results obtained in the present study indicate that the aqueous extract of Solanum aethiopicum is a potent source of anti-inflammatory agents and this justified its uses in the treatment of various infections